Solubility of isoniazid in supercritical carbon dioxide

Document Type

Article

Publication Date

1-1-2010

Abstract

Solubility data of isoniazid in supercritical carbon dioxide are important in selecting the most appropriate supercritical methods for pharmaceutical material processing, such as the micronization of isoniazid or the production of isoniazid composites. The solubility of isoniazid in supercritical carbon dioxide was measured using a dynamic analytical method at temperatures of (308, 311, and 313) K and pressures ranging from (13.0 to 18.5) MPa. The result showed that isoniazid solubility increased with the increase of pressure at an isothermal condition and it also increased with the increase of temperature. The experimental data were correlated using the Chrastil and Mendez-Santiago and Teja models. The calculated results show good agreement with the experimental data.

Publication Title

Journal of Chemical and Engineering Data

ISSN

0021-9568

Divisions

fac_eng

Volume

55

Issue

6

Publisher

American Chemical Society

Publisher Location

1155 16TH ST, NW, WASHINGTON, DC 20036 USA

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