Oppositinines A and B: New vasorelaxant beta-carboline alkaloids from neisosperma oppositifolia
Document Type
Article
Publication Date
1-1-2010
Abstract
A phytochemical study on the bark of Neisosperma oppositifolia (Apocynaceae) yielded two new beta-carboline indole alkaloids, oppositinines A (1) and B (2), together with five known alkaloids, isoreserpiline, isocarapanaubine, vobasine, 10-methoxydihydrocorynantheol-N-oxide, and ochropposinine oxindole. Structural elucidation of 1 and 2 was performed using 21) NMR methods. Oppositinines A (1) and B (2) showed potent vasorelaxant effects on the rat aorta.
Keywords
Beta-carboline, indole, Neisosperma oppositifolia, Apocynaceae, vasorelaxant activity
Publication Title
Chemical & Pharmaceutical Bulletin
Volume
58
Issue
8
Publisher
Pharmaceutical Soc Japan
Publisher Location
2-12-15 SHIBUYA, SHIBUYA-KU, TOKYO, 150-0002, JAPAN
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