Oppositinines A and B: New vasorelaxant beta-carboline alkaloids from neisosperma oppositifolia

Authors

• K. Ahmad
• N.F. Thomas
• A.H.A. Hadi
• M.R. Mukhtar
• K. Mohamad
• M.A. Nafiah
• K. Takeya
• H. Morita
• M. Litaudon
• H. Arai
• Khalijah AwangFollow

Document Type

Article

Publication Date

1-1-2010

Abstract

A phytochemical study on the bark of Neisosperma oppositifolia (Apocynaceae) yielded two new beta-carboline indole alkaloids, oppositinines A (1) and B (2), together with five known alkaloids, isoreserpiline, isocarapanaubine, vobasine, 10-methoxydihydrocorynantheol-N-oxide, and ochropposinine oxindole. Structural elucidation of 1 and 2 was performed using 21) NMR methods. Oppositinines A (1) and B (2) showed potent vasorelaxant effects on the rat aorta.

Keywords

Beta-carboline, indole, Neisosperma oppositifolia, Apocynaceae, vasorelaxant activity

Publication Title

Chemical & Pharmaceutical Bulletin

Recommended Citation

Ahmad, K.; Thomas, N.F.; Hadi, A.H.A.; Mukhtar, M.R.; Mohamad, K.; Nafiah, M.A.; Takeya, K.; Morita, H.; Litaudon, M.; Arai, H.; and Awang, Khalijah, "Oppositinines A and B: New vasorelaxant beta-carboline alkaloids from neisosperma oppositifolia" (2010). Research Publications (2006 to 2010). 3846.
https://knova.um.edu.my/research_publications_2006_2010/3846

Volume

58

Issue

8

Publisher

Pharmaceutical Soc Japan

Publisher Location

2-12-15 SHIBUYA, SHIBUYA-KU, TOKYO, 150-0002, JAPAN