Lumutinines A-D, linearly fused macroline-macroline and macroline-sarpagine bisindoles from alstonia macrophylla
Document Type
Article
Publication Date
1-1-2010
Abstract
Four new linearly fused bisindole alkaloids, lumutinines A D (1-4), were isolated from the stem-bark extract of Alstonia macrophylla. Lumutinines A (1) and B (2) represent the first examples of linear, ring A/F-fused macroline-macroline-type bisindoles, while lumutinines C (3) and D (4) were constituted from the union of macroline and sarpagine moieties. A reinvestigation of the stereochemical assignment of alstoumerine (8) by NMR and X-ray diffraction analyses indicated that the configuration at C-16 and C-19 required revision.
Publication Title
Journal of Natural Products
Volume
74
Issue
12
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