Influenza vaccine concurrently administered with a combination measles, mumps, and rubella vaccine to young children
Document Type
Article
Publication Date
1-1-2010
Abstract
Children aged 11 to <24 months received 2 intranasal doses of live attenuated influenza vaccine (LAIV) or placebo, 35 +/- 7 days apart. Dose 1 was administered concomitantly with a combined measles, mumps, and rubella vaccine (Priorix). Seroresponses to measles and mumps were similar between groups. Compared with placebo, response rates to rubella in LAIV+Priorix recipients were statistically lower at a 15IU/mL threshold (83.9% vs 78.0%) and the prespecified noninferiority criteria were not met. In a post hoc analysis using an alternate widely accepted threshold of 10IU/mL, the noninferiority criteria were met (93.4% vs 89.8%). Concomitant administration with Priorix did not affect the overall influenza protection rate of LAIV (78.4% and 63.8% against antigenically similar influenza strains and any strain, respectively). (C) 2009 Elsevier Ltd. All rights reserved.
Keywords
Combined vaccines, Live attenuated influenza vaccine, Measles-mumps-rubella vaccine, Vaccine interference
Publication Title
Vaccine
Volume
28
Issue
6
Publisher
Elsevier
Publisher Location
THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND