Influenza vaccine concurrently administered with a combination measles, mumps, and rubella vaccine to young children
Document Type
Article
Publication Date
1-1-2010
Abstract
Children aged 11 to <24 months received 2 intranasal doses of live attenuated influenza vaccine (LAIV) or placebo, 35 +/- 7 days apart. Dose 1 was administered concomitantly with a combined measles, mumps, and rubella vaccine (Priorix). Seroresponses to measles and mumps were similar between groups. Compared with placebo, response rates to rubella in LAIV+Priorix recipients were statistically lower at a 15IU/mL threshold (83.9% vs 78.0%) and the prespecified noninferiority criteria were not met. In a post hoc analysis using an alternate widely accepted threshold of 10IU/mL, the noninferiority criteria were met (93.4% vs 89.8%). Concomitant administration with Priorix did not affect the overall influenza protection rate of LAIV (78.4% and 63.8% against antigenically similar influenza strains and any strain, respectively). (C) 2009 Elsevier Ltd. All rights reserved.
Keywords
Combined vaccines, Live attenuated influenza vaccine, Measles-mumps-rubella vaccine, Vaccine interference
Publication Title
Vaccine
Recommended Citation
Lum, L.C.S.; Borja-Tabora, C.F.; Breiman, R.F.; Vesikari, T.; Sablan, B.P.; Chay, O.M.; Tantracheewathorn, T.; Schmitt, H.J.; Lau, Y.L.; Bowonkiratikachorn, P.; Tam, J.S.; Lee, B.W.; Tan, K.K.; Pejcz, J.; Cha, S.; Gutierrez-Brito, M.; Kaltenis, P.; Vertruyen, A.; Czajka, H.; Bojarskas, J.; Brooks, W.A.; Cheng, S.M.; Rappaport, R.; Baker, S.; Gruber, W.C.; and Forrest, B.D., "Influenza vaccine concurrently administered with a combination measles, mumps, and rubella vaccine to young children" (2010). Research Publications (2006 to 2010). 3646.
https://knova.um.edu.my/research_publications_2006_2010/3646
Volume
28
Issue
6
Publisher
Elsevier
Publisher Location
THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND