Explosive HIV-1 subtype B' epidemics in Asia driven by geographic and risk group founder events
Document Type
Article
Publication Date
1-1-2010
Abstract
We explored the timescale, spatial spread, and risk group population structure of HIV-1 subtype B', the cause of explosive blood-borne HIV-1 epidemics among injecting drug users (IDUs) and former plasma donors (FPDs) in Asia. Sequences from FPDs in China formed a distinct monophyletic cluster within subtype B'. Further analysis revealed that subtype B' was founded by a single lineage of pandemic subtype B around 1985. Subsequently, the FPD cluster appears to have derived from a single subtype B' lineage around 1991, corroborating the hypothesis that FPD outbreaks stemmed from the preceding epidemic among IDUs in Southeast Asia, most likely from the Golden-Triangle region. (C) 2010 Elsevier Inc. All rights reserved.
Keywords
HIV-1 subtype B', Injecting drug user (IDU), Former plasma donor (FPD), Phylogeny, Bayesian coalescent analysis, Time of the most recent common ancestor (tMRCA), Southeast Asia, China
Publication Title
Virology
Volume
402
Issue
2
Publisher
Elsevier
Publisher Location
525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA