Eucophylline, a tetracyclic vinylquinoline alkaloid from leuconotis eugenifolius
Document Type
Article
Publication Date
1-1-2010
Abstract
Eucophylline (1), a new tetracyclic vinylquinoline alkaloid, was isolated from the bark of Leuconotis eugenifolius together with leucophyllidine (2). The structure and absolute configuration of 1 were elucidated on the basis of 2D NMR correlations and simulated CD analysis. Leucophyllidine (2) showed iNOS inhibitory activity and decreased the iNOS protein expression dose-dependently.
Publication Title
Journal of Natural Products-Copublished with the Am. Soc. of Pharmacognosy
Volume
73
Issue
10
Publisher
American Chemical Society
Publisher Location
1155 16TH ST, NW, WASHINGTON, DC 20036 USA
COinS