Eucophylline, a tetracyclic vinylquinoline alkaloid from leuconotis eugenifolius

Authors

• J. Deguchi
• T. Shoji
• A.E. Nugroho
• Y. Hirasawa
• T. Hosoya
• O. Shirota
• Khalijah AwangFollow
• A.H.A. Hadi
• H. Morita

Document Type

Article

Publication Date

1-1-2010

Abstract

Eucophylline (1), a new tetracyclic vinylquinoline alkaloid, was isolated from the bark of Leuconotis eugenifolius together with leucophyllidine (2). The structure and absolute configuration of 1 were elucidated on the basis of 2D NMR correlations and simulated CD analysis. Leucophyllidine (2) showed iNOS inhibitory activity and decreased the iNOS protein expression dose-dependently.

Publication Title

Journal of Natural Products-Copublished with the Am. Soc. of Pharmacognosy

Recommended Citation

Deguchi, J.; Shoji, T.; Nugroho, A.E.; Hirasawa, Y.; Hosoya, T.; Shirota, O.; Awang, Khalijah; Hadi, A.H.A.; and Morita, H., "Eucophylline, a tetracyclic vinylquinoline alkaloid from leuconotis eugenifolius" (2010). Research Publications (2006 to 2010). 3493.
https://knova.um.edu.my/research_publications_2006_2010/3493

Volume

73

Issue

10

Publisher

American Chemical Society

Publisher Location

1155 16TH ST, NW, WASHINGTON, DC 20036 USA