Ardeemins and cytochalasins from aspergillus terreus residing in Artemisia annua
Document Type
Article
Publication Date
1-1-2010
Abstract
Three new alkaloids, 15b-dehydro-5-N-acetylardeemin (3), 10-phenyl-[12]-cytochalasins Z16 (6) andZ17(7), were characterized from the liquid culture of the endophytic fungus Aspergillus terreus IFB-E030 along with six known derivatives, 5-N-acetylardeemin (1), 15b-beta-hydroxyl-5-N-acetylardeemin (2), cytochalasin E (4), rosellichalasin (5), cytochalasins Z11 (8), and Z13 (9). The structures of the new metabolites were established mainly by a combination of their 1D- and 2D-NMR spectra, single crystal X-ray diffraction, and the modified Mosher reaction. Biological assays indicated that cytochalasin Z17 (7) had moderate cytotoxicity against human nasopharyngeal epidermoid tumor KB cell line with an IC(50) value of 26.2 mu M.
Keywords
Structure determination, natural products, Aspergillus terreus, ardeemin, cytochalasin
Publication Title
Planta Medica
Volume
76
Issue
14
Publisher
Georg Thieme Verlag Kg
Publisher Location
RUDIGERSTR 14, D-70469 STUTTGART, GERMANY