Anthraquinones with antiplasmodial activity from the roots of rennellia elliptica korth. (Rubiaceae)

Document Type

Article

Publication Date

1-1-2010

Abstract

Dichloromethane root extract of Rennellia elliptica Korth. showed strong inhibition of Plasmodium falciparum growth in vitro with an IC(50) value of 4.04 mu g/mL. A phytochemical study of the dichloromethane root extract has led to the isolation and characterization of a new anthraquinone, 1,2-dimethoxy-6-methyl-9,10-anthraquinone (1), and ten known anthraquinones: 1-hydroxy-2-methoxy-6-methyl-9,10-anthraquinone (2), nordamnacanthal (3), 2-formyl-3-hydroxy-9,10-anthraquinone (4), damnacanthal (5), lucidin-omega-methyl ether (6), 3-hydroxy-2-methyl-9,10-anthraquinone (7), rubiadin (8), 3-hydroxy-2-methoxy-6-methyl-9,10-anthraquinone (9), rubiadin-1-methyl ether (10) and 3-hydroxy-2-hydroxymethyl-9,10-anthraquinone (11). Structural elucidation of all compounds was accomplished by modern spectroscopic methods, notably 1D and 2D NMR, IR, UV and HREIMS. The new anthraquinone 1, 2-formyl-3-hydroxy-9,10-anthraquinone (4) and 3-hydroxy-2-methyl-9,10-anthraquinone (7) possess strong antiplasmodial activity, with IC(50) values of 1.10, 0.63 and 0.34 mu M, respectively.

Keywords

Anthraquinone, Rennellia elliptica, antiplasmodial, Rubiaceae

Publication Title

Molecules

Volume

15

Issue

10

Publisher

MDPI AG

Publisher Location

KANDERERSTRASSE 25, CH-4057 BASEL, SWITZERLAND

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