Document Type
Article
Publication Date
1-1-2006
Abstract
Thalassaemia is an inherited blood disorder and is a significant public health problem in Malaysia, with many not knowing they carry gene for thalassaemia. The two major forms are alpha and beta thalassaemia. An individual can co-inherit both the alpha and beta thalassaemia genes. This study determined the frequency of cincurrent carriers of alpha thalassaemia in 231 beta thalassaemia carriers. Gap-PCR was done on extracted DNA of the beta thalassaemia samples to check for alpha thalassaemia 1 molecular defect. Eight (3.5) samples were found to have concurrently inherited the alpha thalassaemia 1 deletion. The significant carrier rare for alpha thalassaemia 1 indicates the need for the implementation of DNA analysis to complement thalassaemia screening in high risk populations.
Keywords
Thalassaemia, Concurrent carries, screening, gene interaction
Publication Title
Medical Journal of Malaysia
ISSN
0300-5283
Recommended Citation
Chong, Y.M.; Tan, J.; Zubaidah, Z.; Rahimah, A.; Kuldip, K.; and George, E., "Screening of concurrent alpha-Thalassaemia 1 in beta-Thalassaemia carriers" (2006). Research Publications (2006 to 2010). 279.
https://knova.um.edu.my/research_publications_2006_2010/279
Divisions
fac_med
Volume
61
Issue
2
Publisher
Malaysian Medical Association
Additional Information
Department of Molecular Medicine, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA