Document Type
Article (Restricted)
Publication Date
1-1-2009
Abstract
Thermal stability of pharmaceutical ingredients is an important aspect. In this study, we adopted differential scanning calorimetry (DSC) to investigate thermal stability of suppository bases, theobroma oil (cocoa butter) and a palm kernel oil (PKO) blend. The study shows theobroma oil possesses six polymorphic forms whilst the palm kernel oil blend has three. Upon rescanning, the PKO blend does not show changes in the enthalpy of fusion and the melting point with time, whilst the theobroma oil shows significant reduction, and only regained its thermal stable state after 10 days. This indicates that PKO blend possesses better thermal stability.
Keywords
Differential scanning calorimetry (DSC), palm kernel oil (PKO)
Divisions
fac_med
Publication Title
Journal of Thermal Analysis and Calorimetry
Volume
95
Issue
3
Additional Information
Noordin, M. I. Chung, L. Y. 15th International Conference on Biological Calorimetry May 24-30, 2008 Pecs, HUNGARY