Document Type

Article

Publication Date

1-1-2009

Abstract

Acorus calamus (Family: Araceae), available in India and many parts of world, found to have various Pharmacological activities such as analgesic, anti-convulsant, anti-spasmodic, anti-inflammatory, anti-bacterial, anti ulcer and cyto-protective. In present study, we have investigated effects of methanol (ACME) and acetone (ACAE) extract of Acorus calamus leaves against APM induced stereotypy and haloperidol induced catalepsy. APM induced stereotypy behavior, which reached peak at 15 min period. ACME (20 and 50 mg/Kg oral) administration significantly reversed stereotypy induced by APM. But ACAE at doses used (5, 20 and 50 mg/Kg oral) could not alter the stereotypy induced by APM. Whereas ACME (50 mg/Kg) and ACAE (20, 50 mg/Kg) administration significantly potentiated the haloperidol induced catalepsy in mice.

Keywords

Acorus calamus, Catalepsy, stereotypy

Publication Title

International Journal of PharmTech Research

ISSN

0974-4304

Divisions

fac_med

Volume

1

Issue

4

Publisher

Sphinx Knowledge House

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