Document Type
Article (Restricted)
Publication Date
1-1-2006
Abstract
Boesenbergia rotunda (L.) cyclohexenyl chalcone derivatives, 4-hydroxypanduratin A and panduratin A, showed good competitive inhibitory activities towards dengue 2 virus NS3 protease with the K-i values of 21 and 25 mu M, respectively, whilst those of pinostrobin and cardamonin were observed to be non-competitive. NMR and GCMS spectroscopic data formed the basis of assignment of structures of the six compounds isolated. (c) 2006 Elsevier Ltd. All rights reserved.
Keywords
Boesenbergia rotunda (L.) extracts, Cyclohexenyl chalcone derivatives, Dengue 2, NS3 protease, Competitive inhibitory activities
Divisions
fac_med,CHEMISTRY,InstituteofBiologicalSciences
Publication Title
Bioorganic & Medicinal Chemistry Letters
Volume
16
Issue
12
Publisher
Elsevier
Additional Information
Times Cited: 42 Kiat, TS Pippen, R Yusof, R Ibrahim, H Norzulaani, K Rahman, NA