Risk and prognostic significance of tuberculosis in patients from the treat Asia HIV Observational Database
Document Type
Article
Publication Date
1-1-2009
Abstract
To assess the risk and the prognostic significance of tuberculosis (TB) diagnosis in patients from The TREAT Asia HIV Observational Database, a multi-centre prospective cohort of HIV-infected patients receiving HIV care in the Asia-Pacific region. Methods: The risk of TB diagnosis after recruitment was assessed in patients with prospective follow-up. TB diagnosis was fitted as a time-dependent variable in assessing overall survival. Results: At baseline, 22 of patients were diagnosed with TB. TB incidence was 1.98 per 100 person-years during follow up, with predictors including younger age, lower recent CD4 count, duration of antiretroviral treatment, and living in high TB burden countries. Among 3279 patients during 6968 person-years, 142 died (2.04 per 100 person-years). Compared to patients with CDC category A or B illness only, mortality was marginally higher in patients with single Non-TB AIDS defining illness (ADI), or TB only (adjusted HR 1.35, p = 0.173) and highest in patients with multiple non-TB AIDS or both TB and other ADI (adjusted HR 2.21, p < 0.001). Conclusion: The risk of TB diagnosis was associated with increasing immunodeficiency and partly reduced by antiretroviral treatment. The prognosis of developing TB appeared to be similar to that following a diagnosis of other non-TB ADI.
Divisions
fac_med
Publication Title
BMC Infectious Diseases
Volume
9
Publisher
BMC
Additional Information
Zhou, Jialun Elliott, Julian Li, Patrick C. K. Lim, Poh Lian Kiertiburanakul, Sasisopin Kumarasamy, Nagalingeswaran Merati, Tuti Parwati Pujari, Sanjay Chen, Yi-Ming A. Phanuphak, Praphan Vonthanak, Saphonn Sirisanthana, Thira Sungkanuparph, Somnuek Lee, Christopher K. C. Kamarulzaman, Adeeba Oka, Shinichi Zhang, Fujie Tau, Goa Ditangco, Rossana