Leuconicines A−G and (−)-Eburnamaline, Biologically Active Strychnan and Eburnan Alkaloids fromLeuconotis
Document Type
Article
Publication Date
1-1-2009
Abstract
Seven new indole alkaloids of the Strychnos type, leuconicines A-G (1-7), and a new eburnan alkaloid, (-)-eburnamaline (8), were isolated from the stem-bark extract of two Malayan Leuconotis species. The structures of these alkaloids were established using NMR and MS analysis and in the case of 8 also by partial synthesis. Alkaloids 1-5 reversed multidrug resistance in vincristine-resistant KB cells. © 2009 American Chemical Society and American Society of Pharmacognosy.
Keywords
Drug Resistance, Multiple, Drug Screening Assays, Antitumor, Humans, Indole Alkaloids, KB Cells, Malaysia, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Plant Bark, Plant Stems, Stereoisomerism, Vincristine
Divisions
CHEMISTRY
Publication Title
Journal of Natural Products
Volume
72
Issue
12
Publisher
American Chemical Society