Leuconicines A−G and (−)-Eburnamaline, Biologically Active Strychnan and Eburnan Alkaloids fromLeuconotis

Document Type

Article

Publication Date

1-1-2009

Abstract

Seven new indole alkaloids of the Strychnos type, leuconicines A-G (1-7), and a new eburnan alkaloid, (-)-eburnamaline (8), were isolated from the stem-bark extract of two Malayan Leuconotis species. The structures of these alkaloids were established using NMR and MS analysis and in the case of 8 also by partial synthesis. Alkaloids 1-5 reversed multidrug resistance in vincristine-resistant KB cells. © 2009 American Chemical Society and American Society of Pharmacognosy.

Keywords

Drug Resistance, Multiple, Drug Screening Assays, Antitumor, Humans, Indole Alkaloids, KB Cells, Malaysia, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Plant Bark, Plant Stems, Stereoisomerism, Vincristine

Publication Title

Journal of Natural Products

ISSN

0163-3864

Divisions

CHEMISTRY

Volume

72

Issue

12

Publisher

American Chemical Society

This document is currently not available here.

Share

COinS