Differential expression of aldolase, alpha tubulin and thioredoxin peroxidase in peripheral blood mononuclear cells from dengue fever and dengue hemorrhagic fever patients
Document Type
Article
Publication Date
1-1-2009
Abstract
We determined the differential expression levels of proteins in peripheral blood mononuclear cells of patients with dengue fever (DF) and dengue hemorrhagic fever (DHF). Proteins were subjected to two-dimensional electrophoresis, mass spectrometry and Western blot analysis. We identified 8 proteins that were 2-fold or more LIP-regulated in patients compared to healthy control, three of which, aldolase, thioredoxin peroxidase and alpha tubulin, were related to dengue infection. Both thioredoxin peroxidase and alpha tubulin were over-expressed 4.9 and 3.3 times respectively in DHF compared to DF patients while aldolase was up-regulated 2.2 times in DF compared to DHF patients. Alpha tubulin and thioredoxin peroxidase have the potential to be utilized as biomarkers for DHF.
Divisions
fac_med
Publication Title
Southeast Asian Journal of Tropical Medicine and Public Health
Volume
40
Issue
1
Additional Information
Times Cited: 1 Thayan, Ravindran Huat, Tan Lian See, Lucy Lum Chai Khairullah, Nor Shahidah Yusof, Rohana Devi, Shamala