Differential expression of aldolase, alpha tubulin and thioredoxin peroxidase in peripheral blood mononuclear cells from dengue fever and dengue hemorrhagic fever patients

Document Type

Article

Publication Date

1-1-2009

Abstract

We determined the differential expression levels of proteins in peripheral blood mononuclear cells of patients with dengue fever (DF) and dengue hemorrhagic fever (DHF). Proteins were subjected to two-dimensional electrophoresis, mass spectrometry and Western blot analysis. We identified 8 proteins that were 2-fold or more LIP-regulated in patients compared to healthy control, three of which, aldolase, thioredoxin peroxidase and alpha tubulin, were related to dengue infection. Both thioredoxin peroxidase and alpha tubulin were over-expressed 4.9 and 3.3 times respectively in DHF compared to DF patients while aldolase was up-regulated 2.2 times in DF compared to DHF patients. Alpha tubulin and thioredoxin peroxidase have the potential to be utilized as biomarkers for DHF.

Publication Title

Southeast Asian Journal of Tropical Medicine and Public Health

ISSN

0125-1562

Divisions

fac_med

Volume

40

Issue

1

Additional Information

Times Cited: 1 Thayan, Ravindran Huat, Tan Lian See, Lucy Lum Chai Khairullah, Nor Shahidah Yusof, Rohana Devi, Shamala

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