Document Type
Article (Restricted)
Publication Date
3-10-2008
Abstract
The bark extract of Melicope subunifoliolata (Stapf) T.G. Hartley showed competitive muscarinic receptor binding activity. Six polymethoxyflavones [melibentin (1);melisimplexin(3);3,30,40,5,7pentamethoxyflavone(4);melite rnatin (5); 3,5,8-trimethoxy-30,40,6,7 bismethylenedioxyflavone (6); and isokanugin (7)] and one furanocoumarin [5-methoxy-8-geranyloxypsoralen (2)]were isolated fromthe bark extract. Compounds 2 and 6 were isolated for the first time from M. subunifoliolata. Themethoxyflavones (compounds 1, 3, 4, 5, 6, and 7) show moderate inhibition in a muscarinic receptor binding assay, while the furanocoumarin (compound 2) is inactive. The potency of the methoxyflavones to inhibit [ 3 H]NMS-muscarinic receptor binding is influenced by the position and number of methoxy substitution. The results suggest these compounds are probably muscarinic modulators, agonists or partial agonists/antagonists.
Keywords
Melicope Subunifoliolata, Rutaceae, Flavonoid, Muscarinic Receptor
Divisions
fac_med
Publication Title
Phytochemistry
Volume
69
Issue
7
Publisher
Elsevier
Additional Information
Corresponding author. Tel.: +603 79674909; fax: +603 79674964. E-mail addresses: chungly@hotmail.com, chungly@um.edu.my