Comparison of serum F2 isoprostane levels in diabetic patients and diabetic patients infected with Burkholderia pseudomallei
Document Type
Article
Publication Date
2-1-2008
Abstract
The oxidative stress theory proposes that severe sepsis leads to activation of neutrophils and macrophages which subsequently release reactive oxygen-free radicals that may result in lipid peroxidation of endothelial and epithelial cell membrane phospholipids. This chain reaction results in increased levels of isoprostanes, which are thought to contribute to much of the end-stage tissue damage seen in serious infections, such as melioidosis. We believe that this is the first report linking in vivo oxidative stress status and diabetic patients infected with B. pseudomallei.
Keywords
Burkholderia pseudomallei, Case-Control Studies
Divisions
fac_med
Publication Title
Singapore Medical Journal
Volume
49
Issue
2
Publisher
Stamford Publishing Pte Ltd / Singapore Medical Association
Additional Information
Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia