Document Type
Article (Restricted)
Publication Date
1-1-2008
Abstract
This study reportsa sequential biopanning against serum obtained from a patient infected with B. pseudomallei using a phage display peptide library. A peptide bearing the consensus sequence NKNSFDAWLQSF was obtained after 3 rounds of biopanning and it partly resembles the sequence 35FDAWLAAQEF44 of B. pseudomallei site-specific recombinase, which is a phage integrase family protein. Overall, the mimotope obtained in this study could be a potential candidate for the development of a cost effective diagnostic test or vaccine in the future.
Keywords
Burkholderia pseudomallei, melioidosis, phage display, mimotope
Divisions
fac_med
Publication Title
Journal of Applied Sciences
Volume
8
Issue
21
Additional Information
Department of Molecular Medicine, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSI