Document Type
Article (Restricted)
Publication Date
1-1-2008
Abstract
This study reportsa sequential biopanning against serum obtained from a patient infected with B. pseudomallei using a phage display peptide library. A peptide bearing the consensus sequence NKNSFDAWLQSF was obtained after 3 rounds of biopanning and it partly resembles the sequence 35FDAWLAAQEF44 of B. pseudomallei site-specific recombinase, which is a phage integrase family protein. Overall, the mimotope obtained in this study could be a potential candidate for the development of a cost effective diagnostic test or vaccine in the future.
Keywords
Burkholderia pseudomallei, melioidosis, phage display, mimotope
Publication Title
Journal of Applied Sciences
ISSN
1812-5654
Recommended Citation
Chua, K.H.; Chai, H.C.; and Puthucheary, S.D., "Identification of Burkholderia pseudomallei Mimotope using Phage display approach" (2008). Research Publications (2006 to 2010). 1481.
https://knova.um.edu.my/research_publications_2006_2010/1481
Divisions
fac_med
Volume
8
Issue
21
Additional Information
Department of Molecular Medicine, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSI