Document Type
Article (Restricted)
Publication Date
1-1-2008
Abstract
Nicotine replacement therapies (NRT) are prescribed in smoking cessation programmes to help smokers stop smoking. The ideal dosage of NRT should control cravings and withdrawal symptoms but avoid adverse reactions. This report describes a case of adverse reaction to nicotine gum in a female Malay smoker. Assays taken 2 h after the gum, showed that her plasma cotinine/nicotine ratio was 0.4, indicating poor nicotine metabolic status. She developed nausea, severe vomiting and diarrhoea with raised blood pressure and pulse rate, following the administration of a piece of 2 mg nicotine gum on an empty stomach. This was observed in the course of a study to determine nicotine metabolism. Nicotine gum may be associated with adverse reactions in those with poor nicotine metabolic rate. Further investigation is required into the clinical effects of nicotine gum in those with poor nicotine metabolic status.
Keywords
Smoking
Publication Title
International Journal of Mental Health and Addiction
ISSN
1557-1874
Recommended Citation
Noorzurani, M.H.R.; Bond, A.; and Wolff, K., "Adverse reaction to nicotine gum in malay female smoker: a case report" (2008). Research Publications (2006 to 2010). 1307.
https://knova.um.edu.my/research_publications_2006_2010/1307
Divisions
fac_med
Volume
6
Issue
4
Additional Information
Department of Primary Care Medicine, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA