Pathogenicity of Porphyromonas asaccharolytica in Adult Periodontitis of Malaysian Samples
Document Type
Article
Publication Date
1-1-2008
Abstract
Bacterial toxin of Porphyromonas asaccharolytica strains obtained from adult periodontitis were analysed using mouse model. Results from subcutaneous injection with whole bacterial cells of 108 and 1010 cells mL-1 failed to induce any infection. However when bacterial concentration of 1012 cells mL-1 was used, all P. asaccharolytica strains were able to induced the development of localized lesion on balb/c mice. In addition, infected mice appeared cachectic with ruffled hair. Thus, infection with the latter concentration was pathogenic and was dose dependent. The toxin was also found to be heat labile for all strains. Therefore, we conclude that the extracellularly toxin produced by P. asaccharolytica of our local isolates which were obtained from adult periodontitis, is virulent and heat labile.
Keywords
Pathogenicity, Porphyromonas asaccharolytica, Adult Periodontitis, Malaysian Samples
Divisions
Dentistry
Publication Title
Current Research in Bacteriology
Volume
1
Issue
1
Publisher
Asian Network for Scientific Information