A Case of T-Cell Acute Lymphoblastic Leukemia after Treatment of Acute Promyelocytic Leukemia
Document Type
Article
Publication Date
5-1-2004
Abstract
We diagnosed T-cell acute lymphoblastic leukemia (T-ALL) with multiple cytogenetic abnormalities in a 17-year-old girl a year after she had received a diagnosis of acute promyelocytic leukemia (APML). After the diagnosis of APML in June 2001, the patient was treated with idarubicin and all-trans-retinoic acid. In September 1999, her younger sister also received a diagnosis of APML and to date has remained well. T-ALL after remission of APML is very rare, and only 1 such case has been reported. Possible causes include therapy-related reasons, genetic susceptibility to leukemia, and environmental exposure.
Keywords
Therapy-related leukemia, T-cell acute lymphoblastic leukemia, Acute promyelocytic leukemia, Familial leukemia
Divisions
fac_med
Publication Title
International Journal of Hematology
Volume
79
Issue
4
Publisher
Springer Verlag (Germany)