Document Type
Article
Publication Date
1-1-2004
Abstract
A series of 3-chloroquinoxaline-2-carboxamides were designed and prepared by the condensation of 3-chloro-2-quinoxaloylchloride with appropriate Mannich bases of the p-aminophenol in the microwave environment. The synthesized compounds were evaluated for serotonin(3) (5-HT3) receptor antagonistic activities in longitudinal muscle-myenteric plexus (LMMP) preparation from guinea pig ileum against the 5-HT3 agonist, 2-methyl-5-HT. Compound 3g exhibited comparable 5-HT3 antagonistic activity (pA(2) 6.4) to that of standard antagonist Ondansetron (pA(2) 6.9), while the other compounds exhibited mild to moderate 5-HT3 antagonistic activities.
Keywords
quinoxalinecarboxamide, Mannich base, serotonin3 (5-HT3) receptor antagonist
Publication Title
Biological & Pharmaceutical Bulletin
ISSN
0918-6158
Recommended Citation
Mahesh, R.; Perumal, R.V.; and Pandi, P.V., "Pharmacophore based synthesis of 3-chloroquinoxaline-2-carboxamides as serotonin(3) (5-HT3) receptor antagonist" (2004). Research Publications (2000 to 2005). 944.
https://knova.um.edu.my/research_publications_2000_2005/944
Divisions
fac_med
Volume
27
Issue
9
Additional Information
Mahesh, R Perumal, RV Pandi, PV