Document Type
Article
Publication Date
1-1-2003
Abstract
The rate of formation and disappearance of phthalic anhydride (PAn) intermediate in the aqueous cleavage of N-methoxyphthalamic acid (NMPA) under acidic pH was studied spectrophotometrically in mixed CH3CN-H2O solvents. The rate of formation of PAn from NMPA is almost independent of the change in acetonitrile content from 20 to 70% v/v in mixed aqueous solvents. The rate constants for the formation of PAn from NMPA are similar to10-fold smaller than the corresponding rate constants for the formation of PAn from o-carboxybenzohydroxamic acid (OCBA). These observations are ascribed to the consequence of the occurrence of slightly different mechanisms in these reactions.
Keywords
Alkaline-Hydrolysis, Phthalic-Anhydride, Aqueous Cleavage, Primary Amines, Aminolysis, Catalysis, Model
Divisions
CHEMISTRY
Publication Title
Organic & Biomolecular Chemistry
Volume
1
Issue
8
Additional Information
Department of Chemistry, Faculty of Science Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA