Document Type

Article

Publication Date

1-1-2003

Abstract

A six-week-old male infant was admitted for investigation of cholestasis and pale stools. He became lethargic and apnoeic with prolonged seizures after a percutaneous liver biopsy. Subsequent investigations showed conjugated hyperbilirubinaemia, elevated liver enzymes, and hypoglycaemia. The radinuclide hepatobiliary scintigraphy was non-excretory. After an operative cholangiogram, the infant developed Addisonian-like crisis with bradycardia, hypotension, respiratory distress, metabolic acidosis, hypoglycaemia, hyponatraemia, and hyperkalaemia. Blood investigations confirmed congenital hypopituitarism. Hormone replacement therapy with L-thyroxine and cortisone acetate resulted in dissolution of jaundice and the reduction of the liver size.

Keywords

Cogenitial hypopituitarism, cholestasic jaundice, addisonian-like crisis

Publication Title

Medical Journal of Malaysia

ISSN

0300-5283

Divisions

fac_med

Volume

58

Issue

2

Publisher

Malaysian Medical Association

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