Elevated Serum Transforming Growth Factor β1 Levels in Epstein-Barr Virus-Associated Diseases and Their Correlation with Virus-Specific Immunoglobulin A (IgA) and IgM

Authors

• Jingwu Xu
• Ali Ahmad
• James F. Jones
• Riccardo Dolcetti
• Emanuela Vaccher
• Umapati Prasad
• José Menezes

Document Type

Article

Publication Date

1-1-2000

Abstract

Transforming growth factor β (TGF-β) is an immunosuppressive cytokine which can induce immunoglobulin A (IgA) switch and Epstein-Barr virus (EBV) replication in latently infected cells. Here we report elevated serum levels of TGF-β in various EBV-associated diseases correlating positively with EBV- specific IgA titers and negatively with IgM titers, suggesting a role for this cytokine in the pathogenesis of these diseases.

Keywords

Antibodies, Viral, Epstein-Barr Virus Infections, Herpesvirus 4, Human, Humans, Immunoglobulin A, Immunoglobulin M, Regression Analysis, Transforming Growth Factor beta

Publication Title

Journal of Virology

ISSN

0022-538X

Recommended Citation

Xu, Jingwu; Ahmad, Ali; Jones, James F.; Dolcetti, Riccardo; Vaccher, Emanuela; Prasad, Umapati; and Menezes, José, "Elevated Serum Transforming Growth Factor β1 Levels in Epstein-Barr Virus-Associated Diseases and Their Correlation with Virus-Specific Immunoglobulin A (IgA) and IgM" (2000). Research Publications (2000 to 2005). 37.
https://knova.um.edu.my/research_publications_2000_2005/37

Divisions

fac_med

Volume

74

Issue

5

Publisher

American Society for Microbiology