Elevated Serum Transforming Growth Factor β1 Levels in Epstein-Barr Virus-Associated Diseases and Their Correlation with Virus-Specific Immunoglobulin A (IgA) and IgM
Document Type
Article
Publication Date
1-1-2000
Abstract
Transforming growth factor β (TGF-β) is an immunosuppressive cytokine which can induce immunoglobulin A (IgA) switch and Epstein-Barr virus (EBV) replication in latently infected cells. Here we report elevated serum levels of TGF-β in various EBV-associated diseases correlating positively with EBV- specific IgA titers and negatively with IgM titers, suggesting a role for this cytokine in the pathogenesis of these diseases.
Keywords
Antibodies, Viral, Epstein-Barr Virus Infections, Herpesvirus 4, Human, Humans, Immunoglobulin A, Immunoglobulin M, Regression Analysis, Transforming Growth Factor beta
Divisions
fac_med
Publication Title
Journal of Virology
Volume
74
Issue
5
Publisher
American Society for Microbiology
COinS