Document Type
Article
Publication Date
1-1-2000
Abstract
Dicentrine is a known a,-adrenoceptor antagonist,but its a,-adrenoceptor subtype selectivity has not yet been determined. We therefore, investigated the putative a, adrenoceptor subtype selectivity of this agent. METHODS; Graded isometric contractile responses of rat aotric rings and spleen to phenylephrine were observed in the absence or presence of various concentrations of dicentrite. The pA2 values for dicentrine were determined. RESULTS; Aortic tissues were more sensitive to phenylephrine-induced contraction than the spleen tissues.Dicentrine was approximately 100 times more potent as an antagonist to the aortic contraction, than it was to the splenic contractions. CONCLUSION: Dicentrine is an a,-adrenoceptor antagonist which is more selective towards the putative a,D-adrenoceptor subtype of the rat aorta than the ale-adrenoceptor of the spleen
Keywords
Undera Megaphylla, Dicentrine, Aporphines, Adrenergic Alpha-Antagonists, Aorta, Spleen
Divisions
fac_med
Publication Title
Acta Pharmacologica Sinica
Volume
21
Issue
12
Additional Information
Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur 57(X10, Malaysia