Microwave-assisted solvent-free synthesis of 3- (4-substituted piperazin-1-yl)alkyl imidazo 2,1-b 1,3 benzothiazol-2(3H)-ones as serotonin(3) (5-HT3) receptor antagonists
Document Type
Article
Publication Date
1-1-2005
Abstract
A series of novel 3-(4-substituted piperazin-1-yl)alkylimidazo2,1-b1,3benzothiazol-2(3H)-ones were prepared by microwave irradiation using alumina as solid support and also by a conventional method. The compounds were characterized by spectral data and the purity was ascertained by microanalysis. The synthesized compounds were evaluated for 5-hydroxytryptamine(3) antagonisms in a longitudinal muscle-myenteric plexus preparation from guinea pig ileum against the 5-hydroxytryptamine3 agonist, 2-methyl-5-hydroxytryptamine. Among the test compounds, 3-2-(4-methylpiperazin-1-yl)ethylimidazo2,1-b1,3benzothiazol-2(3H)-one (3b) showed most favorable 5-hydroxytryptamine3 antagonism (pA(2) 6.7) in the isolated guinea pig ileum.
Divisions
fac_med
Publication Title
Pharmazie
Volume
60
Issue
6
Additional Information
Mahesh, R Perumal, RV Pandi, PV