Structure−Activity Relationship of Polyisoprenyl Benzophenones fromGarcinia pyriferaon the Tubulin/Microtubule System
Document Type
Article
Publication Date
1-1-2000
Abstract
Microtubule disassembly inhibitory properties have been established for the known polyisoprenylated benzophenones xanthochymol (1a) and guttiferone E (1b). The compounds were isolated from the fruits of Garcinia pyrifera collected in Malaysia. A structure - activity relationship study, including natural and semisynthetic derivatives, delineated some structural features necessary for the interaction with tubulin within this compound class.
Keywords
Benzophenones, Butadienes, Chromatography, Gel, Chromatography, High Pressure Liquid, Fruit, Gas Chromatography-Mass Spectrometry, Hemiterpenes, Humans, KB Cells, Magnetic Resonance Spectroscopy, Malaysia, Microtubules, Optical Rotation, Pentanes, Plants, Medicinal, Rosales, Spectrophotometry, Infrared, Spectrophotometry, Ultraviolet, Structure-Activity Relationship, Tubulin
Divisions
CHEMISTRY
Publication Title
Journal of Natural Products
Volume
63
Issue
8
Publisher
American Chemical Society