Unusual diarylheptanoid-phenylpropanoid adducts and diarylheptanoid alkaloids from Pellacalyx saccardianus

Authors

• Zi-Yang Chan
• Premanand Krishnan
• Ling -Wei Hii
• Chun-Wai Mai
• Chee-Onn Leong
• Yun-Yee LowFollow
• Soon-Kit Wong
• Kang-Nee Ting
• Kien -Thai YongFollow
• Kuan-Hon Lim

Document Type

Article

Publication Date

12-1-2021

Abstract

Two pairs of enantiomeric diarylheptanoid-phenylpropanoid adducts bearing a cyclohexenone core, (+/-)-sac-cardianones A and B (1 and 2), an alkaloidal diarylheptanoid-phenylpropanoid adduct bearing a 4-piperidone core, (+/-)-saccardianine A (3), a pair of enantiomeric dimeric diarylheptanoid alkaloids bearing a tetrahy-dropyridine core, (+/-)-saccardianine B (4), and a suspected degradation product, saccardianine C (5), in addition to a known diarylheptanoid, platyphyllenone (6), were isolated from the leaves of Pellacalyx saccardianus. Their chemical structures were elucidated based on detailed analyses of the NMR and MS data. The structure of (+/-)-(1) was also confirmed by X-ray diffraction analysis. Compounds (+/-)-2 and 6 exhibited selective cytotoxicity to-wards the AsPC-1 and PANC-1 pancreatic cancer cell lines, respectively.

Keywords

Pellacalyx saccardianus, Rhizophoraceae, Diarylheptanoid, Alkaloid, X-ray crystallography, Cytotoxicity

Publication Title

Phytochemistry Letters

Recommended Citation

Chan, Zi-Yang; Krishnan, Premanand; Hii, Ling -Wei; Mai, Chun-Wai; Leong, Chee-Onn; Low, Yun-Yee; Wong, Soon-Kit; Ting, Kang-Nee; Yong, Kien -Thai; and Lim, Kuan-Hon, "Unusual diarylheptanoid-phenylpropanoid adducts and diarylheptanoid alkaloids from Pellacalyx saccardianus" (2021). Research Publications (2021 to 2025). 7804.
https://knova.um.edu.my/research_publications_2021_2025/7804

Divisions

Science

Volume

46

Publisher

Elsevier

Publisher Location

RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS